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I'm excited to share a new pre-print, where we explore novel effects of maternal death on offspring fitness across eight populations of seven primate species: biorxiv.org/content/10.110.
Done in collaboration with the Primate Life Histories Database (plhdb.org)
1/23
I'm Just A Boi!
Both Katy And I Have Never Been In A Serious Relationship With The Opposite Sex. Don't You Find That Odd? We're In Our Late 30s, But We've Never Been In A Real Relationship With A Male And Female, Respectively. Why Do You Think This Is The Case? I Think It's Because Our Mother Gave Birth To Us When She Was In Her 40s, So We May Have Inherited Some Genetic Mutations Related To Personality Traits (The Older A Mother Is When She Gives Birth, The More Likely Her Offspring Will Inherit Deleterious Mutations) And, More Importantly, We Were Raised In A Strict, Religious Household Further Building On Whatever Personality Traits That Have Inclined Us To Be Sexually Repressed, Prudes!
OR MAYBE IT'S BECAUSE OUR FATHER WAS OLDER! I DON'T KNOW! BUT READ BELOW!
Kevin Mitchell Retweeted
80% of de novo mutations in people arise from sperm (rathe than oocyte) & the number of mutations increases with paternal age, so the number of mutations in a child from a 40 year old Dad is 2x that of a 20 year old Dad...Paternal age matters @jorisveltman
Why do kids of older fathers have higher rates of psychiatric illness? http://www.nature.com/ng/journal/vaop/ncurrent/full/ng.3577.html …
A report published this week in JAMA Psychiatry confirmed this trend. It is a huge study of data about 2.6 million Swedish-born children and reveals that a guy like me, who became a father at 45 (I was 46, actually), would be three or four times more likely to have a child with autism spectrum disorder.
Miss Jackson If You Nasty!
I DON'T HAVE A CHILD. I BELIEVE IN EUGENICS. ARE YOU NOT READING WHAT I'M WRITING? NO, YOU'RE NOT. AT LEAST YOU'RE NOT UNDERSTANDING IT. AND WHY ARE YOU NOT READING IT AND UNDERSTANDING IT? BECAUSE YOU'RE GENETICALLY INFERIOR AND I WOULD NEVER EVER HAVE A CHILD WITH YOU. (UM, I'M 35. IF YOU'RE A FEMALE THAT'S MY AGE OR OLDER, I'M NOT INTERESTED IN YOU (I'M NOT INTERESTED IN DEVELOPING A SEXUAL RELATIONSHIP WITH YOU AND I'M DEFINITELY NOT INTERESTED IN HAVING A CHILD WITH YOU. THERE'S AN EVOLUTIONARY REASON FOR THIS. WANT ME TO EXPLAIN IT? OK. FEMALES REACH THEIR PEAK FERTILITY IN THEIR EARLY 20s. AFTER THIS PERIOD THEIR FERTILITY DECREASES SUBSTANTIALLY. SO, AS A 35 YEAR OLD MALE I'D BE DOING MORE HARM THAN GOOD TO MYSELF (I'D BE LIMITING MY REPRODUCTIVE POTENTIAL) BY DEVELOPING A RELATIONSHIP WITH A FEMALE THAT'S MY AGE OR OLDER*. AS A MATTER OF FACT, I CAN TAKE THIS ONE STEP FURTHER AND SAY THAT DEVELOPING A SEXUAL RELATIONSHIP WITH ANY FEMALE OVER THE AGE OF 30 WOULD NOT BE IN MY BEST INTEREST BECAUSE THE FERTILITY AND FECUNDITY OF FEMALES THIS AGE IS DRASTICALLY LOWER THAN THAT OF FEMALES IN THEIR REPRODUCTIVE PRIME (EARLY 20s). PLUS, AS FEMALES AGE, ESPECIALLY ONCE THEY'RE PAST THEIR REPRODUCTIVE PRIME, THEY BEGIN DEVELOPING MORE MUTATIONS (PARTICULARLY DELETERIOUS ONES IN THEIR SEX CELLS) AND THERE'S A GREATER CHANCE OF PASSING ON THESE MUTATIONS TO ANY OFFSPRING THAT THEY MAY HAVE AT THIS LATER REPRODUCTIVE AGE. (THE BEST TIME TO HAVE CHILDREN IS WHEN YOU'RE IN YOUR REPRODUCTIVE PRIME AND FOR FEMALES THIS IS THE TIME FROM MENARCHE TO ABOUT YOUR LATE 20s. WHY IS THIS THE BEST TIME TO CONCEIVE OFFSPRING? BECAUSE YOUR EGG CELLS (AND SPERM CELLS FOR MEN) ARE IN THEIR BEST CONDITION, FOR LACK OF A BETTER PHRASE. THEY'RE AT THEIR MOST VIGOROUS, POTENT, AND HIGH QUALITY STATE AT THIS TIME.)
*I CAN TELL BY LOOKING AT YOUR FACE AND BODY THAT YOU'RE PAST YOUR REPRODUCTIVE PRIME. I CAN ESPECIALLY TELL BY LOOKING AT YOUR FACE BECAUSE IT'S LESS SYMMETRICAL AND LESS TAUT. (AS FEMALES AGE THEIR REPRODUCTIVE POTENTIAL DECREASES MUCH MORE SWIFTLY AND SIGNIFICANTLY THAN IT DOES FOR MALES. FEMALES ARE ONLY GOOD FROM THEIR EARLY TEENS TO LATE TWENTIES. MALES, ON THE OTHER HAND, ARE GOOD FROM THEIR EARLY TEENS UNTIL DEATH. GOOOOOOD!)
"The female rate of facial aging is higher than the male rate. Before age 50, female faces age—on average—about twice as fast as male faces; between 50 and 60 years, this sex difference in aging rate is even more pronounced (up to three times faster)."
This Is Especially The Case Among European Females And Their European Female Descendants Throughout The World! Their European Genes Make Them Particularly Susceptible To Rapid Facial Aging!
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https://blogs.scientificamerican.com/guest-blog/wait-is-that-your-father-or-your-grandfather/
A better understanding of fatherhood and aging requires us to dust off our anthropologist hats and venture to societies that are not Western, Educated, Industrial, Rich, and Democratic, or WEIRD, as evolutionary psychologist Joseph Henrich has dubbed us.
Demographers often assumed that men generally stopped reproducing around the age of fifty, which coincides with women experiencing menopause. Assuming that most humans, or at least those that are WEIRD, are monogamous, this is a reasonable assumption. The problem with this idea is that many members of our species are not WEIRD, and it is likely that those in our evolutionary past may not have been so devoted to having a single mate.
This includes both males and females, but for now we’re keeping our Darwinian gaze on the men. Evolutionary demographer Shripad “Tulja” Tuljapurkar and colleagues analyzed male fertility in several non-WEIRD societies and found that fatherhood at older ages, say after the age of fifty, was not only evident, but more commonplace compared to WEIRD societies. Therefore one can make the assumption that fatherhood at older ages was likely common in our evolutionary past and that older fathers contributed to the emergence of traits that define us as a species.
The emergence of fatherhood at older ages provides an explanation for the long period of post-reproductive life in women and humans in general. The lifespan of most organisms usually coincides with the loss of their ability to reproduce. In women, that is around the age of fifty with the onset of menopause. However, in humans, almost a third of our lifespan is post-menopausal, which is very unusual regardless of whether you’re WEIRD or not. If men were able to reproduce at older ages, a trait that is very uncommon among primates and animals in general, this may have selected for longevity genes that were passed to both sons and daughters. In other words, older fathers may have contributed to the evolution of long lives in humans. Thank you, Mick and Ronnie.
My Father Impregnated My Mother When He Was 45! I'll Probably Be In My 40s If/When I Have A Child! So...Read Above! I'm Just Gonna Repeat The Cycle! (My Mother W
as 43 When She Had ME And 45 When She Had Katy! That's Why We Crazy!)
"older eggs are more likely to have genetic problems of the sort that can lead to Down syndrome...Though the risk remains low—a 40-year-old mother has a 1-in-75 chance. That's up from one in fourteen hundred in her twenties." a.co/d/35wOFPb
Steve Stewart-Williams
Your maternal grandmother carried a little part of you in her womb. Girls are born with all the eggs they'll ever produce. So, when your grandmother was carrying your mother, your mother was carrying the egg that later grew into you. Pretty. Damn. Cool. https://me.me/i/grandma-mom-me-this-is-so-amazing-did-you-know-21349284 …
Your maternal grandmother carried a little part of you in her womb. Girls are born with all the eggs they'll ever produce. So, when your grandmother was carrying your mother, your mother was carrying the egg that later grew into you. Pretty. Damn. Cool. https://me.me/i/grandma-mom-me-this-is-so-amazing-did-you-know-21349284 …
...the egg that ultimately made us was formed when our mothers were embryos and their ovaries were formed...the way in which sperm are formed and the way eggs develop are very different. Post-pubertal males produce sperm continuously throughout their reproductive lives and store it from ejaculate to ejaculate in their seminal vesicles. So depending on the frequency of our father's sexual activity, the sperm that contributed 50 percent of our genes in all probability was formed in his testes on the days before our conception. But in contrast, all the eggs a woman possesses are formed in the first few weeks of her intrauterine existence. So half the genetic material at conception may be only a few days old, but the other half will be many years old...The egg which contributes to the baby's genotype has already had a long life and may have been subject to a range of environmental factors, whilst the sperm has probably had a very brief existence before fertilization. Is it possible that the evolutionary advantage of the mother developing all her eggs before she is born derives from the opportunity this presents for them to be influenced by the environment inside the grandmother's womb* - a sort of female memory effect? The egg from a woman who conceives in her forties is much older than if she had conceived in her twenties. Older eggs are probably not as robust as younger ones and may have been subject to the ravages of ageing. This may explain why women become less fertile after their mid-thirties. This is a biological reality that has become a social concern as more women choose to delay having a family until later in life, and then find that their fertility is not as they hoped...The more recent part of our individual journey started when our mother was an embryo and the egg destined to make each of us formed in one of her developing ovaries while she was still inside our maternal grandmother's womb. We have seen how the environment of that egg as it was fertilized and grew to be our mother, who in turn incubated each of us and created an environment in which we grew, has influenced us. After we were born other factors influenced our biology in many ways. These environmental messages from our many pasts have set constraints on our current biology...As our previous discussion on ageing has suggested, there is an inherent biological trade-off between the energy expended to keep cells alive and functioning and energy devoted to reproduction. Eggs must be nurtured to stay alive by the cells surrounding them in the ovary so that they can be fit to ovulate. It seems as if we evolved so that eggs have a finite life of a maximum of fifty years, remembering that many are lost or have declined in viability before then. Sufficient survive to allow healthy reproduction until towards the end of the fourth decade and then maintenance beyond that point is energetically wasteful. Then look at the other possibility. Certainly women show a decline in fertility from well before menopause - starting around 35 years of age. This may reflect the phenomenon of ageing eggs but there may well also be an adaptive advantage in doing so... (Mismatch: The Lifestyle Diseases Timebomb)
*"I'm Killin' The Pussy, The Punani! I'm Gettin' All Up In Her Mammy An Her Granny!" - Diggidy Dazzle
*"I'm Killin' The Pussy, The Punani! I'm Gettin' All Up In Her Mammy An Her Granny!" - Diggidy Dazzle
- 🇺🇸 @Mangan150
Advantages to sons of higher paternal age: older fathers produce sons with higher 'geekiness', correlated w success https://www.nature.com/tp/journal/v7/n6/full/tp2017125a.html …
SQUARE Pronounced SE-QWAY-YUH
https://www.psychologytoday.com/blog/the-scientific-fundamentalist/200901/i-m-mac-and-i-pursue-the-scientific-truth-any-cost
What’s New
Investigators looked at the history of over 50,000 women over the age of 44 to determine if there was any correlation between the age at which their mothers delivered them and the likelihood these women exited their birthing years (up to age 44) childless.
What The Study Showed:
Women born to older mothers were far more likely to exit their fertile years without a child. After adjusting for numerous confounders (education, birth order, marital status, ethnicity), women born to mothers over age 35 were nearly 40% more likely to remain childless than women born to mothers age 20 – 24.
While the medical profession has no clearly accepted definition of when advanced paternal age begins -- it ranges from 35 to 45 -- infants born to fathers over 45 have risen 10 percent in the United States over the past 40 years, likely due to assisted reproductive technology.
The study found that men 45 and older can experience decreased fertility and put their partners at risk for increased pregnancy complications such as gestational diabetes, preeclampsia and preterm birth. Infants born to older fathers were found to be at higher risk of premature birth, late still birth, low Apgar scores, low birth weight, higher incidence of newborn seizures and birth defects such as congenital heart disease and cleft palate. As they matured, these children were found to have an increased likelihood of childhood cancers, psychiatric and cognitive disorders, and autism.
Bachmann attributes most of these outcomes to a natural decline in testosterone that occurs with aging, as well as sperm degradation and poorer semen quality, but she said that some correlations need more research. "In addition to advancing paternal age being associated with an increased risk of male infertility, there appears to be other adverse changes that may occur to the sperm with aging. For example, just as people lose muscle strength, flexibility and endurance with age, in men, sperm also tend to lose 'fitness' over the life cycle," she said.
Damage to sperm from stresses of aging can lead to a decrease in sperm number and a change in the sperm and egg that is passed from parent to offspring and becomes incorporated into the DNA of cells in the offspring's body. "In addition to decreasing fertilization potential, this can also influence the pregnancy itself, as is noted by increased pregnancy risks when conception is successful," she said.
These germline or heredity mutations also may contribute to the association of advancing paternal age and disorders in the offspring, such as these children being diagnosed with autism and schizophrenia. "Although it is well documented that children of older fathers are more likely to be diagnosed with schizophrenia -- one in 141 infants with fathers under 25 versus one in 47 with fathers over 50 -- the reason is not well understood," she said. "Also, some studies have shown that the risk of autism starts to increase when the father is 30, plateaus after 40 and then increases again at 50."
Second, because Longoria is seven years older than Parker, their marriage is unfortunately doomed to be short-lived. Of course, Hollywood marriages typically don’t last long (and there is an evolutionary psychological reason for that), but the fact that Longoria is so much older than Parker will be an additional factor in their short-lived marriage. I would predict that their marriage will end before Longoria turns 40.
WHY DID SATOSHI'S PREDICTION COME TRUE? BECAUSE LONGORIA WAS NO LONGER IN HER REPRODUCTIVE PRIME AND, IN FACT, REPRODUCTIVELY DETERIORATING ON A DAILY BASIS AS SHE CLOSED IN ON MENOPAUSE! TONY UNCONSCIOUSLY RECOGNIZED THIS VIA FACIAL CUES, BODILY CUES, AND PHEROMONES LEADING HIM TO LEAVE HER! WHY STAY WITH A WOMAN IF SHE'S NO LONGER REPRODUCTIVELY VIABLE?
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